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The affinity of PF-06882961 (K i = 80 nM) measured using this new radioligand was 4.5-fold more potent and more consistent with its cAMP potency, whereas the clinical peptides had similar affinities using both radioligands (Table S6)

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Chronic ethanol exposure leads to an increase in Ca-ATPase activity and in the presence of phenylephrine, the enzyme activity is further enhanced