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The onset of lipid peroxidation within biological membranes is associated with changes in their physicochemical properties and with alteration of biological function of lipids and proteins
Upon activation, calcineurin dephosphorylates and stimulates TFEB, which in turn translocates into the nucleus where it binds to the coordinated lysosomal expression and regulation (CLEAR) sequence to upregulate expression of several genes involved in the autophagic pathway (Tong and Song, 2015
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