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Specific Evidence for No IGF-1 Effects: Blood samples collected at baseline and throughout the treatment period measured serum IGF-1 concentrations using validated immunoassays

Additionally, SIRT1 activation reduces de novo lipogenesis (fat synthesis from carbohydrates), decreasing fat accumulation

Phase III is funded from a private or non-SBIR government source for commercialization or continued development and testing from an effort made under prior SBIR funding

Animal Circadian Studies Experiments examined melatonin and cortisol rhythms in aged rhesus monkeys and melatonin-related measurements in rodents

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