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Tong L, Zhang X, Hao H, Liu Q, Zhou Z, Liang X, et al

The reason retatrutide and the approved GLP-1s are titrated up over months is side effects: in the Phase 2 trial, jumping to high doses without titration nearly doubled gastrointestinal side effects for the same weight loss (The Lancet, 2023)

Injections are also used when rapid restoration of B12 levels is needed or when oral supplements arent effective

In older populations from the PREDIMED and InCHIANTI studies, individuals with higher urinary (poly) phenol excretion exhibited better cardiovascular health indicators, including glucose and triglyceride levels, blood pressure, and body weight (Guo et al., 2016)