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The intricate structural and biochemical interactions between skeletal muscle and the vascular endothelium facilitate optimal nutrient and oxygen transport, the clearance of metabolic byproducts, and the release of myokines and vasculokines that mutually regulate their respective functions (3, 4)

Rather than a thumbs-up or thumbs-down, this review works through those credentialing signals one at a time, in fair-balance fashion, as of April 2026