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Pevec D, Novinscak T, Brcic L, Sipos K, Jukic I, Staresinic M, et al

As people age, their bodies may become less efficient at absorbing vitamin B12 from food due to changes in stomach acid production or gastrointestinal function

The link between depression and chronic pain: neural mechanisms in the brain

Their analysis revealed that GHK-Cu modulates approximately 4,000 human genes, with notable effects on genes involved in DNA repair, antioxidant defence, the ubiquitin-proteasome system, and the suppression of pro-inflammatory pathways such as NF-kB signalling

This may happen through transcriptional inhibition via NF-B/AP-1 pathways or by altering methyl donor availability (Hassan et al., 2019)