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The pathways of the differential metabolites in HW treatments were associated with amino acids and phenolic metabolisms, which were strongly related to an enhanced antioxidative capacity, particularly, metabolites involved in arginine and proline metabolism, and phenylpropanoid and flavonoid biosynthesis

As expected, intrahepatic protein and RNA levels as well as serum levels of TNF rapidly increased at 1, 2 and 6 h post-PH in WT mice, respectively (Figures 4a, b and d)

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