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Besides, berberine can prevent NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome from being activated during the inflammation process of Parkinsons disease and restore autophagy activity to protect dopamine neurons ( In addition to the above studies, in the zebrafish Parkinsons disease model, berberine derivatives can be used to treat Parkinsons disease

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Lifestyle modificationincluding dietary interventions, weight loss, and increased physical activityremains the cornerstone of MASLD management, with sustained 7%10% weight loss demonstrating improvement in steatosis, inflammation, and even fibrosis (19)