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Low-selenium diet, bone, and articular cartilage in rats

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In order to improve the effect of gene therapy in regulating ferroptosis in OA, many studies in recent years have been devoted to optimizing the delivery system to overcome the complexity and barriers of the intra-articular environment (180)

Experimental studies demonstrated that many peptides, including insulin and calcitonin, exhibit intestinal half-lives measured in minutes rather than hours (Mahato et al., 2003)