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Specifically, thanks to Megan Mazzei for engaging in thoughtful discussions about the conflicting effects of G6PD-d on immune cells, and Tanmoy Mondal for his thoughts on the effect of G6PD-d on T cells

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Benefits of IM Delivery: Faster peak blood concentration Suitable for peptides requiring quick response (e.g., PEG-MGF) Useful for large-volume injections Drawbacks: Can be more painful Higher risk of tissue damage or improper injection Less ideal for long-term peptide therapies IM peptide injections result in rapid systemic exposure, but may lead to inconsistent depot formation and localized degradation. Fosgerau & Hoffmann, Drug Discovery Today Oral Peptide Delivery: Why Its So Challenging (and Whats Changing) Oral delivery is the most convenient route for medications but for peptides, its also the most problematic

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doi: 10.1016/j.canlet.2016.07.035 26 BhattacharyyaSSahaSGiriKLanzaIRNairKSJenningsNBet al