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When any component of this system becomes damaged, inflamed, or degenerative, the resulting pain can range from mild discomfort to debilitating agony that affects every aspect of daily life

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Fe 2+ is not only the leading participant in the Fenton reaction during ferroptosis but also causes ferroptosis through other programs

Human mild traumatic brain injury decreases circulating branched-chain amino acids and their metabolite levels

In brief, lipid peroxidation forms toxic lipid free radicals and serves as a trigger for ferroptosis, especially when excess iron ions exist in the cytoplasm