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The lead author of that study, Professor Donna Ryan from Pennington Biomedical Research Center, New Orleans, USA, said: Our long-term analysis of semaglutide establishes that clinically relevant weight loss can be sustained for up to four years in a geographically and racially diverse population of adults with overweight and obesity but not diabetes

It should be used cautiously in patients with a history of epilepsy

and affect neurogenesis and neural differentiation, synapses, myelination and neuroinflammation development [72,73]

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Because insulin resistance often increases fat storage, it can contribute to weight gain