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They found that obesity drugs and weight-loss surgery proved far superior to diet and exercise, which resulted in an average weight loss of 7.4% those pounds were typically regained within four years

An external small-molecule GLP-1 that can be taken with food would be complementary because it removes the final barrier to mass oral adoption

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For example, previous studies have noted a decrease in preference for starchy foods (Wharton et al., 2022), dairy (Friedrichsen et al., 2021, Wharton et al., 2022), sweets (Friedrichsen et al., 2021, Kadouh et al., 2020, Gibbons et al., 2021), savory foods (Friedrichsen et al., 2021, Kadouh et al., 2020), and high-fat foods (Blundell et al., 2017, Gibbons et al., 2021, Kadouh et al., 2020)