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Et de faon plus gnrale : les mauvaises habitudes de vie, linflammation, un choc septique, une infection, radiations et rayonnements UV, anesthsies et chirurgies rptes, intoxications aux mtaux lourds, stress rpts, alimentation industrielle et junk food Lexposition aux xnobiotiques et endognes (pollution en gnral, fumes, prise rgulire de mdicaments, agents pathognes, etc) acclrent la surcharge en toxines du foie et diminuent les niveaux cellulaires ce qui va entrainer des lsions cellulaires

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Hesperidin can regulate lipid metabolism (upregulating PPAR, CPT1, ACOX1, and ACADM, downregulating HADH, SREBP-1C, and SCD1) and the gut microbiota (mainly increasing the Bacteroidetes / Firmicutes ratio), participating in the regulation of lipid metabolism ( Firmicutes / Bacteroidetes ratio and the abundance of Bacteroidetes and Lactobacillus ) ( In summary, the research found that botanical drugs and their active metabolites can participate in regulating the gut microbiota and SCFAs levels, improving bile acid metabolism, modulating related hormones of the BGA, and regulating inflammatory factors