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Hubs analysis identified highly connected nodes within the protein network, which may correspond to residues or regions of the protein that are involved in multiple interactions

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Given the time frame of symptom onset of 8.5 weeks after initiation of statin therapy and normalization of aminotransferases after only medication cessation without additional therapy, it is conceivable that the cholestatic liver injury was secondary to atorvastatin use

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PMID: 30282322 | doi:10.1016/j.ejmech.2018.08.062 Gouda M et al