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62,63,64 Lipid metabolism also plays an active role in regulating Treg function

A 2026 review in JAAOS Global Research and Reviews covered therapeutic peptides in orthopaedics (PMID 41490200)

Loinard C, Zouggari Y, Rueda P, et al

There is interest among researchers in using IGF-1 DES as a potential treatment in hyperglycemia were it would have similar effects to insulin administration without the long-term side effects that can occur if too much insulin is used

Once GH enters circulation, the liver converts much of it into insulin-like growth factor 1 (IGF-1), which is the downstream mediator responsible for most of GH's tissue-level effects lean mass preservation, lipolysis, cellular repair, and collagen synthesis among them