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Ginkgetin, 179 PRLX93936 180 and falnidamol 181 can reverse chemotherapy resistance of non-small cell lung cancer cells by inducing ferroptosis via Nrf2-GSH axis or DUSP26 pathway

The inclusion of glutathione in both clinical treatments and over-the-counter wellness products reflects growing recognition of its role in supporting long-term health and quality of life

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Paradoxically, this same mechanism may underlie its potential pro-cancer effects: by boosting GSH production, cancer cells can better protect themselves from oxidative damage caused by ROS (Ramachandran and Jaeschke, 2021)