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Las guas de la American Diabetes Association (ADA) y del American College of Physicians (ACP) recomiendan evaluar peridicamente la necesidad continua del tratamiento, considerando los objetivos teraputicos alcanzados, la tolerabilidad y las preferencias del paciente

Subsequent studies using two HTG mouse models demonstrated that, compared with control mice, HTG mice presented delayed pancreatic regeneration, marked by impaired morphological restoration and disrupted cellular responses, including fibrotic inflammation and acinar cell proliferation

The structural shift caused by C-terminal truncation and S129p possibly unmasks the hydrophobic core and facilitates aberrant, nonfunctional intermolecular interactions

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