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We anticipate that emerging companies focusing on these potential differentiations, particularly with combinable incretins (e.g., GLP-1, GIP, GCG, PPY) and complementary non-incretin MOAs, could capture a meaningful market share in the future

Moreover, GLP-1R cascade also has interactions to regulatory proteins involved in the insulin receptor cascades such as the insulin receptor substrates (IRS) and the PI3K involved in the positive regulation for survival, metabolism and proliferation of beta pancreatic cells as well as apical glucose transport in peripheral tissues

The drug also decreased the expression of tauS596 protein and increased the expression of synapse-related proteins in the hippocampus (79)

Non-motor symptoms such as cognitive impairment, depression, anxiety, sleep disturbances, and autonomic dysfunction are also common and significantly impact quality of life