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Lactobacillus plantarum Lac16 alleviates dextran sodium sulfate-induced colitis in mice by suppressing NLRP3 inflammasome overactivation through microbiota-derived isobutyric acid

Last year, FDA called on PCAC to evaluate whether a dozen peptide drugs should be eligible for compounding by licensed facilities

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These may include inhibitors of production/antagonists of the action of pro-inflammatory cytokines (e.g., infliximab) (Maini, 2004), compounds that decrease the production of adhesion molecules (e.g., -amyrin) (Shih and Cherng, 2014), antibodies targeting adhesion molecules (Siles et al., 2018), or compounds that compete with phagocytes to bind the endothelium (Pans et al., 1999)

(2024, February 29)