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It should be noted that, while the tolerability and efficacy profile of the GLP-1R agonist/GIPR antagonizing antibody maridebart cafraglutide warrants enthusiasm, it has not yet been directly compared to GLP-1R agonism or dual GLP-1R/GIPR agonism in the clinical setting

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Nutrition Insight speaks with the authors of a recent JAMA manuscript who warn that synthetic peptides are moving quickly from research into mainstream markets

In addition to its role in protein metabolism, GPER regulates fatty acid metabolism and the cell cycle, potentially modulating amino acid synthesis and degradation to protect cells from metabolic stress and maintain protein balance [3, 86]