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We do not recommend self-administering B12 or any supplementation without proper medical guidance, as unnecessary supplementation may mask underlying health issues

In the REDEFINE 1 phase 3 trial (NCT05567796), which enrolled adults with overweight or obesity (BMI 27 kg/m) and at least 1 weight-related comorbidity but without type 2 diabetes, participants receiving CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) achieved a mean body weight reduction of 22.7% from baseline after 68 weeks among adherent participants, compared with approximately 3% in the placebo group.5 These results establish CagriSema as one of the most potent antiobesity therapies investigated to date

[DOI] [PubMed] [Google Scholar] 203.Reinecke M

Inhibiting NNMT has been shown to reverse diet-induced obesity, reactivate aged muscle stem cells, and normalize metabolic biomarkers all without affecting appetite or food intake

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