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AngIV: Angiotensin IV

However, the effect of glutamate on cataracts remains unclear, as subcutaneous administration of monosodium L-glutamate to newborn mice induces cataracts 29

GCL is a heterodimeric enzyme composed of a glutamate-cysteine ligase catalytic subunit (GCLC), which confers enzymatic activity, and a glutamate-cysteine ligase modifier subunit (GCLM), which enhances GCLC efficiency and attenuates feedback inhibition by GSH

This multi-pathway approach is exciting from a therapeutic standpoint its like orchestrating an overall healing response rather than targeting one single receptor

These are uncommon, but they suggest a need for caution in people with known high hematocrit, clotting disorders or myeloproliferative conditions