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SCD1 downregulation attenuates GCSC tumorigenicity and the metastasis-dependent HippoYAP pathway in vivo To determine whether SCD1 affects tumour growth and metastasis in vivo, SCD1-KD HSC034 cells and cells treated with A939572 or oxaliplatin were injected subcutaneously or via the tail vein into SCID mice

Sirtuin-3, a nuclear protein translocated to the mitochondrial matrix upon oxidative stress (Klotz et al., 2015), plays an important role in mitochondrial bioenergetics and defense to oxidative stress

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