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Individuals with type 2 diabetes may experience more pronounced first-month weight loss due to improved glycemic control, which reduces water retention and metabolic inflammation

Sackmann-Sala L, Kopchick JJ (2015)

Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling

And then they looked at non secondary or secondary endpoints, things like non fatal cardiovascular events which are all part of the composite endpoint PVD leading to amputation, non fatal stroke or death from any cause

Interest in selective motilin receptor agonists remains high, offering promise in treating GI hypomotility syndromes