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Moreover, interindividual heterogeneity driven by genetic variation (particularly VDR polymorphisms), metabolic comorbidities, and chronic low-grade inflammation further confounds the predictability of therapeutic efficacy

Participants were obese or had excess weight along with a weight-related medical condition

If cost or access issues force a stop, even a partial taper over two to three weeks is better than nothing

Creative Commons CC-BY license, Obesity is associated with numerous health complications, including type 2 diabetes, cardiovascular disease, metabolic dysfunction-associated steatotic liver disease (MASLD), and certain cancers

Applying these substances directly to the affected area avoids systemic effects associated with oral and intravenous medications