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An analysis of data from 596 PsA patients in the British Society for Rheumatology Biologics Register (BSRBR) found that the safety profile with these agents was not substantially different from that with nonbiologic DMARDs, and that the safety in PsA patients was similar to that seen in serologically negative RA patients

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Nature 439, 589593

It results in a higher percentage of degraded RBCs, thereby reducing the RBC count and causing anemia during sepsis (eryptotic RBCs were degraded and cleared from circulation) [202, 230, 380]