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Interestingly, in a pilot study, exposure of autologous glioma cells treated ex vivo with IGF-1R antisense oligos induced partial tumour regression in some patients with malignant astrocytoma (Andrews et al, 2001)

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Avoid dosing immediately before bed

Duranay M, Akay H, Yilmaz FM, et al

However, when taking higher doses for skin goals, it is important to listen to your body