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This activation promotes synaptogenesis, neurogenesis, and neuronal survival by mimicking or potentiating brain-derived neurotrophic factor (BDNF)-like activity, enhancing synaptic connectivity and cognitive plasticity

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There is also a theoretical risk of increased incidence of skin cancer with loss of melanin in previously protected individuals

Additionally, Baldwin and Kiick reported that NEM adducts of some thiols including N -acetylcysteine may undergo retro and exchange reactions at physiological pH and temperature [45]

This baseline allows objective comparison at three, six, and twelve months