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124 found that prenatal lead exposure was associated with increased gene-specific 5-methylcytosine and 5-hydroxymethylcytosine levels

CoA, coenzyme A

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"Have you seen any adverse side effects?" Robertson asked

While KYN itself is not neuroactive, it is a branching point for two major metabolic routes: one leading to the synthesis of kynurenic acid (KYNA), which occurs in astrocytes, and another leading to the synthesis of picolinic acid (PA) and quinolinic acid (QA), occurring in microglia, with QA serving as a precursor for nicotinamide adenine dinucleotide (NAD) [25, 26]