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The answer is complicated, and researchers do not fully understand every mechanism yet

2,6675,333 mcg of total blend once daily, titrated upward gradually across an 812 week course (about 1020 units )

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Evidence suggests that patients with CKD are prone to increased incidence of ischemic strokes, with cognitive dysfunction, dementia, transient infarcts, and white matter lesions widespread in mild to moderate CKD patients (Chelluboina and Vemuganti, 2019)