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The main drawbacks of such methods are the difficulty of achieving cell type-specific profiling if suitable surface markers (that can be targeted by antibodies) are unavailable and, for future applications, the challenge of delivering large antibody reagents and high-intensity light into animals and tissue

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The field of delivery vehicles encompasses lipid-based, polymeric, and inorganic nanoscaffolds, as well as antibody-PROTAC conjugates (DACs) and aptamer-PROTAC hybrids (APCs), providing multidimensional platforms for crossing biological barriers and achieving antigen-dependent targeting

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Silva-AdayaDPerez-De LaCruzVHerrera-MundoMNMendoza-MacedoKVilleda-HernandezJBiniendaZet al