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Research on discontinuation: SURMOUNT-4 trial examined what happened when people stopped tirzepatide after losing weight Participants regained approximately two-thirds of the weight they had lost within 1 year of stopping Appetite suppression effects end within weeks of the last injection Metabolic adaptations (slower metabolism from weight loss) persist Why regain happens: Medication suppressed appetite

Beolens, Bo

Interestingly, in the liver of PTEN-deficient mice, Nrf2 activation and nuclear localization was observed [38]

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