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This bidirectional NO interaction gives this compound an adaptability in biological environments that single-pathway peptides lack, and may contribute to its consistency of effect across diverse tissue types and experimental conditions

Gray SL, Anderson ML, Dublin S, et al

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Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner

This is an important distinction the osteoarthritis cohort was older and more comorbid