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CHRIS RAYNER: I think it should be regarded as a paradigm shift, but I think the other thing that's worth noting is the additional benefits of this class of therapy as far as cardiovascular protection and renal protection goes

Niacin (nicotinic acid) can cause a temporary skin flushing reaction, which is why niacinamide is often preferred for research applications not focused on cholesterol modulation

Incretin-based agents in type 2 diabetic patients at cardiovascular risk: compare the effect of GLP-1 agonists and DPP-4 inhibitors on cardiovascular and pancreatic outcomes

Exp Clin Endocrinol 102(4):341347 Yamada Y, Tsukiyama K, Sato T, Shimizu T, Fujita H, Narita T (2016) Novel extrapancreatic effects of incretin

Making sure youre meeting 20-30 g of protein per meal can substantially reduce your lean-mass loss