Although ketones dont measure fat loss directly, they can provide insight into whether the body is primarily using fat for fuel and has achieved a state of nutritional ketosis, which may provide metabolic health benefits in addition to weight loss
PMC 5063953
For semaglutide specifically, treatment should be discontinued at least 2 months before a planned pregnancy
5 Pharmacological effects of GIP, GLP-1 and their mimetics The pharmacological benefits of GIP, GLP-1, and their synthetic mimetics arise from their pleiotropic effects, encompassing at least five key functions: bolstering insulin secretion and survival of pancreatic -cells and modulating glucagon release by the pancreatic -cells in response to glycemic levels, acting on the satiety center in brain, slowing gastric emptying, regulating lipid and glucose metabolism through effects on adipose tissue and liver, and reducing systemic blood pressure
Exp Mol Med 54(4):377392 Clemmensen C, Mller TD, Woods SC, Berthoud H-R, Seeley RJ, Tschp MH (2017) Gut-brain cross-talk in metabolic control
