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Novo Nordisk's research showed that higher doses of GLP-1 could correct diabetes in mice and cause weight loss, and it eventually became clear that GLP-1 receptors in the brain were suppressing the desire to eat

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Similar in vitro work showed that HGF promoted dendritic arborization in hippocampal neurons, an effect that could be blocked by NMDA receptor antagonists and was dependent on intracellular calcium and CaMKII activity [2]

This robust pipeline includes drugs that not only target diabetes but also address obesity, recognizing the close link between the two conditions

Notices 2014 , e690950