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Last, we examine the mechanisms by which psychological stressors, translocation of Gram-negative bacteria, viral infections such as SARS-CoV-2 and metabolic syndrome can contribute to neuroimmune imbalances and, consequently, the acute phase of MDD

In our study, by performing metabolite pool and isotopomer labeling analyses, we found that ACTL6A increased GSH de novo synthesis mainly by regulating the synthesis of -GC, the rate-limiting step catalyzed by GCLC

The nucleic acids produced from nucleotide proteolytic hydrolysis are degraded into purine substances, which are then converted into UA by XOD and excreted as UA (99,100)

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McDonald, M