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Alternative splicing of CARM1 mRNA generates two isoforms: full-length CARM1 (automethylated) and exon 15 deleted CARM1E15 (automethylation-defective)

Scientific References: Gwyer D, Wragg NM, Wilson SL., Cell and Tissue Research , 2019

Smith SM, Vale WW (2006) The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

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HIC has been used to determine the drug distribution of several ADCs containing auristatin drugs conjugated to inter-chain cysteines (mAb) and engineered cysteines (THIOMAB) through cleavable and noncleavable linkers 4,9-12