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Serious adverse effects requiring immediate medical attention include signs of pancreatitis (severe abdominal pain radiating to the back), gallbladder disease (right upper quadrant pain, particularly after meals), acute kidney injury (decreased urine output, swelling), or severe allergic reactions

Secondary benefits include blood pressure reduction, IBS symptom relief, and gut microbiome support

Interestingly, activation of GIP receptors in the hindbrain may help reduce the nausea and vomiting often linked to GLP-1 receptor agonists

Lenane, P., Keane, C

Neuroprotection of taurine against bilirubin-induced elevation of apoptosis and intracellular free calcium ion in vivo