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TNF- activates nicotinamide adenine dinucleotide phosphate oxidase (NOX), producing ROS [2], creating a vicious cycle

Patients should report persistent stool changes to their GP, particularly if accompanied by abdominal pain, as GLP-1 therapy carries rare risks of pancreatitis and gallbladder disease

They belong to the group of zinc-dependent matrix metalloproteinases (MMPs), which bind zinc ions to the catalytic site for their activation, forming coenzymes