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Early eat-me signals described in the literature are immature sugar structures that lack sialic acid, and the asialoglycoprotein receptor was found to be responsible for the targeted deposition of apoptotic hepatocytes [215]

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This keeps the blood level constant in a natural range, which is gentler on the body, especially for the liver and kidneys

While gastrointestinal adverse events were more common in the semaglutide group than in the placebo group overall, these were mostly mild to moderate and occurred predominantly in the early titration phase rather than persisting throughout the two-year treatment period

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