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p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells

NF-E2-related factor-2 (Nrf2) is a transcription factor that regulates the expression of antioxidant and phase II detoxifying enzymes

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The criteria below reflect eligibility used in Phase 2 and ongoing Phase 3 clinical studies only and should not be interpreted as future UK licensing or NHS commissioning criteria

While we provide functional context for several loci identified in this study, including TUT4 , RYK , MOXD1 , UBAP2 , GATA5 , and others, we acknowledge that many of these interpretations rely on indirect evidence from related biological pathways or associations with non-ocular traits such as age-related macular degeneration, cardiovascular traits, or metabolic phenotypes