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Mitochondrial-encoded complex i impairment induces a targetable dependency on aerobic fermentation in Hrthle cell carcinoma of the thyroid

In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected

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