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The histidine residue serves as the primary copper-binding site through its imidazole ring, creating a stable square-planar copper(II) complex with the amino terminal and adjacent peptide nitrogen atoms

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Funding This work was supported in part by the Ministry of Science and Technology (2016YFA0502303 and 2015CB910300 to LL),the National Natural Science Foundation of China (21633001 to LL), and the Rudolf Virchow Jr

Oncolytics 3 , 19 (2016)