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Each stage of respiration, from glycolysis in the cytoplasm to the citric acid cycle and oxidative phosphorylation in mitochondria, depends on NAD+/NADH to carry reducing equivalents, thereby driving the production of cellular energy

Similarly, the first in vivo imaging studies in humans, confirmed an increase in OS and a simultaneous decrease in GSH levels in the motor cortex of patients with ALS (with an age of 65.2 9.4 years, and a mean disease duration of 25.8 17.1 months) compared to the controls [106, 107]

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doi:10.1001/jamanetworkopen.2023.27739

Because these systems are biologically distinct, analysts have explored whether they may provide complementary signaling effects