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Cellular and animal models using environmental and biological toxins, especially lipopolysaccharides (LPS), herbicides and pesticides like rotenone or MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), can induce both astrogliosis and microgliosis, which is accompanied by neuronal death, mitochondrial dysfunction and nuclear fragmentation [41-45]

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FDA surveys and academic analyses indicate that a meaningful minority of outsourcing facilities actively produce drugs listed on the FDA shortage list

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