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[PUBMED Abstract] Berwick M, MacArthur J, Orlow I, et al.: MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors

Since these mice have wild-type pain thresholds, and levels of all POMC products, but lack MC1R function, these results strongly suggest that the analgesic effects of SHU9119 are MC1R independent and likely due to ligand effects on MC4R (or MC3R, another related receptor)

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