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The authors found that the seizure duration can be shortened upon activation of ChR2- or HR channels in both laterally and medially localized Purkinje cells, but that the seizure occurrence could only be dampened when the midline Purkinje cells were optogenetically excited

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This dual preservation creates a unique metabolic environment where cells can simultaneously maintain high energy production capacity and robust epigenetic regulation a combination that typically requires careful balance between competing metabolic demands

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