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Immunofluorescence staining also showed a marked increase in the number of Ki-67-positive cells and a decrease in the nuclear content of -H2AX and P21 after FOXO4-DRI treatment (Figures 4B,C)

The proposed rule will have a comment period, and at some point after that comment period closes, the FDA will make the final rule as to whether those ingredients will be on the positive list

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